Ingeborg Krägeloh-Mann Selected Research

Metachromatic Leukodystrophy (Sulfatide Lipidosis)

3/2022	Identification of neurodegeneration indicators and disease progression in metachromatic leukodystrophy using quantitative NMR-based urinary metabolomics.
1/2022	A Mutation-Agnostic Hematopoietic Stem Cell Gene Therapy for Metachromatic Leukodystrophy.
1/2022	Hematopoietic Stem Cell Transplantation with Mesenchymal Stromal Cells in Children with Metachromatic Leukodystrophy.
3/2021	Long-term disease course of two patients with multiple sulfatase deficiency differs from metachromatic leukodystrophy in a broad cohort.
1/2021	Intravenous arylsulfatase A in metachromatic leukodystrophy: a phase 1/2 study.
11/2020	Optimization of Enzyme Essays to Enhance Reliability of Activity Measurements in Leukocyte Lysates for the Diagnosis of Metachromatic Leukodystrophy and Gangliosidoses.
9/2020	Early clinical course after hematopoietic stem cell transplantation in children with juvenile metachromatic leukodystrophy.
9/2020	Safety of intrathecal delivery of recombinant human arylsulfatase A in children with metachromatic leukodystrophy: Results from a phase 1/2 clinical trial.
8/2019	Measurement of recombinant human arylsulfatase A and leukocyte sulfatase activities by analytical isotachophoresis.
11/2017	Enzymatic characterization of novel arylsulfatase A variants using human arylsulfatase A-deficient immortalized mesenchymal stromal cells.

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Ingeborg Krägeloh-Mann Research Topics

Disease

12	Metachromatic Leukodystrophy (Sulfatide Lipidosis) 03/2022 - 02/2009
5	Lysosomal Storage Diseases (Lysosomal Storage Disease) 03/2022 - 10/2006
3	Leukoencephalopathies 01/2020 - 02/2003
3	Hereditary Spastic Paraplegia 01/2020 - 01/2018
3	Movement Disorders (Movement Disorder) 01/2020 - 09/2006
3	Cerebral Palsy (Spastic Diplegia) 01/2018 - 09/2006
3	Paresis (Hemiparesis) 10/2006 - 12/2004
2	Neurodegenerative Diseases (Neurodegenerative Disease) 03/2021 - 10/2020
2	Disease Progression 09/2020 - 02/2002
2	Dystonia (Limb Dystonia) 01/2020 - 01/2019
2	Pontocerebellar Hypoplasia 01/2011 - 09/2008
2	Periventricular Leukomalacia (Neonatal Cerebral Leukomalacia) 04/2007 - 02/2006
1	Esotropia (Esophoria) 03/2022
1	Demyelinating Diseases (Demyelinating Disease) 03/2022
1	Inborn Genetic Diseases (Disease, Hereditary) 01/2022
1	Deglutition Disorders (Dysphagia) 12/2021
1	Ichthyosis (Xeroderma) 03/2021
1	Multiple Sulfatase Deficiency Disease (Mucosulfatidosis) 03/2021
1	Dysostoses 03/2021
1	Cognitive Dysfunction 01/2021
1	Sepsis (Septicemia) 01/2021
1	HIV Infections (HIV Infection) 01/2021
1	Gangliosidoses (Gangliosidosis) 11/2020
1	Birth Weight (Birth Weights) 11/2020
1	Globoid Cell Leukodystrophy (Krabbe Disease) 10/2020
1	Seizures (Absence Seizure) 10/2020
1	Muscle Spasticity (Spastic) 01/2020
1	Chorea (Rheumatic Chorea) 01/2020
1	Parkinsonian Disorders (Parkinsonism) 01/2020
1	Frontotemporal Dementia (Semantic Dementia) 01/2020
1	Cerebellar Ataxia (Dysmetria) 01/2020
1	Huntington Disease (Huntington's Disease) 01/2020
1	Brain Injuries (Brain Injury) 07/2019
1	Brain Diseases (Brain Disorder) 07/2019
1	Fatty Acid Hydroxylase-Associated Neurodegeneration 01/2019
1	Neurodevelopmental Disorders 05/2017
1	Epilepsy (Aura) 05/2017
1	GM2 Gangliosidoses (GM2 Gangliosidosis) 04/2017
1	AB Variant Tay-Sachs Disease 04/2017
1	Sleep Wake Disorders 05/2014
1	Gastroesophageal Reflux (GERD) 05/2014
1	Apnea 05/2014
1	Reinfection 05/2014
1	Ataxia (Dyssynergia) 04/2014
1	Optic Neuritis (Retrobulbar Neuritis) 10/2013
1	Pontocerebellar Hypoplasia Type 6 01/2011
1	Pontocerebellar Hypoplasia Type 1 01/2011
1	Metachromatic Leukodystrophy due to Saposin B Deficiency 02/2009
1	Combined Saposin Deficiency 02/2009
1	Congenital Disorders of Glycosylation 02/2002

Drug/Important Bio-Agent (IBA)

8	Cerebroside-Sulfatase (Arylsulfatase A)IBA 03/2022 - 11/2017
4	EnzymesIBA 03/2021 - 01/2018
3	Sulfoglycosphingolipids (Sulfatides)IBA 03/2022 - 11/2017
3	Lactic Acid (Lactate)FDA LinkGeneric 01/2011 - 02/2003
2	IronIBA 01/2020 - 01/2019
2	LipidsIBA 01/2018 - 02/2009
2	Proteins (Proteins, Gene)FDA Link 04/2014 - 02/2009
2	splicing endonucleaseIBA 01/2011 - 09/2008
2	Botulinum Toxins (Botulinum Toxin)IBA 01/2010 - 09/2006
2	Biological ProductsIBA 04/2007 - 02/2006
1	GadoliniumIBA 03/2022
1	SulfatasesIBA 03/2021
1	N-formylglycineIBA 03/2021
1	GalactosylceramidaseIBA 10/2020
1	Mitochondrial Proteins (Mitochondrial Protein)IBA 01/2020
1	Retinaldehyde (Retinal)IBA 07/2019
1	PhosphatidylglycerolsIBA 01/2018
1	Anticonvulsants (Antiepileptic Drugs)IBA 05/2017
1	SodiumIBA 05/2017
1	Sodium Channels (Sodium Channel)IBA 05/2017
1	Sodium Channel BlockersIBA 05/2017
1	Voltage-Gated Sodium ChannelsIBA 05/2017
1	Hexosaminidase BIBA 04/2017
1	Hexosaminidase A (Hex A)IBA 04/2017
1	G(M2) Activator ProteinIBA 04/2017
1	SteroidsIBA 10/2013
1	Ligases (Synthetase)IBA 01/2011
1	Transfer RNA (tRNA)IBA 01/2011
1	SphingolipidsIBA 02/2009
1	ArylsulfatasesIBA 02/2009
1	Sphingolipid Activator ProteinsIBA 02/2009
1	SaposinsIBA 02/2009
1	Leukoencephalopathy with Brainstem and Spinal Cord Involvement and Lactate ElevationIBA 04/2007
1	Polysaccharides (Glycans)IBA 02/2002
1	Congenital disorder of glycosylation type 1AIBA 02/2002

Therapy/Procedure

3	Hematopoietic Stem Cell Transplantation 01/2022 - 01/2016
3	Transcranial Magnetic Stimulation 10/2006 - 12/2004
2	Enteral Nutrition (Feeding, Tube) 12/2021 - 10/2020
2	Therapeutics 05/2017 - 10/2006
1	Mechanical Ventilators (Ventilator) 01/2021
1	Blood Transfusion (Blood Transfusions) 11/2020
1	Transplantation 09/2020
1	Equine-Assisted Therapy 01/2018
1	Fundoplication 05/2014
1	Gastrostomy 05/2014
1	Plasma Exchange 10/2013
1	Bone Marrow Transplantation (Transplantation, Bone Marrow) 10/2006